The effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis
نویسندگان
چکیده
BACKGROUND Osteoporosis is a chronic disease characterized by a decrease in bone mineral density (BMD) and corruption of the microarchitectural structure of bone tissue. OBJECTIVE It was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in Oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine. MATERIALS AND METHODS Bone Mineral Density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase (ALP) measurements were performed. Obtained results were compared with that of alendronate. RESULTS Oophorectomy induced osteoporosis was exacerbated by methylprednisolone. Alentronate prevented ovariectomised induced osteoporosis, but it couldn't prevent methylprednisolone +ovariectomised induced osteoporosis in rats. CONCLUSION Combined treatment with methylprednisolon and metyrosine was the best treatment for preventing osteoporosis but metyrosine alone couldn't prevent osteoporosis in ovariectomised rats.
منابع مشابه
Effects of catecholamines on the intramedullary pressure in the femur in rats with prednisolone-induced osteoporosis.
Osteoporosis is a metabolic bone disease characterized by low bone mass, impaired micro-architecture and susceptibility to fracture. Osteoporosis may be, inter alia, a result of a long-term glucocorticosteroid therapy, e.g. with prednisolone. Although a number of properties of prednisolone in influencing bone metabolism have been recognized, the effect of prednisolone-induced osteoporosis on th...
متن کاملCombination Effects of Prednisolone and Interleukin-4 Protect Bovine Nasal Cartilage Explants from Interleukin-1α Induced Degradation
Background: Current treatments for joint diseases are moderately successful, but unfortunately are associated with significant side effects. This study was undertaken to investigate the combination effects of IL-4 and prednisolone on tissue characteristics and production of matrix metalloproteinase-1(MMP-1) in IL-lα-treated bovine nasal cartilage (BNC) explants. Methods: BNC explants were cultu...
متن کاملاثر زخم زای پردنیزولون بر روی مخاط معده خرموش و نقش نوتروفیل ها
The ulcerogenic effect of corticosteroids has always been subject of controversial discussion. In this study, which is a part of another extensive study (the role of neutrophil in induction of gastric mucosal injury by different agents), the effect of prednisolone, as a widely used corticosteroid, on the rat gastric mucosa, was investigated. Prednisolone (1 mg/kg) induced acute mucosal injury (...
متن کاملEffects of Adding Dexpanthenol to Prednisolone in an Experimental Model of Inflammatory Bowel Disease
Background & Objective: Inflammatory bowel diseases (IBDs) represent serious chronic auto-inflammatory conditions, affecting the alimentary tract. The beneficial effect of dexpanthenol has been observed on some inflammatory conditions. Here, the therapeutic potential of combined dexpanthenol and prednisolone in alleviating the symptoms of the animal model of IBD was investigated. Materials & M...
متن کاملEffect of pamidronate on the action of catecholamines on blood pressure in the marrow cavity of long bones in rats with prednisolone-induced osteoporosis.
Pamidronate is a representative of bisphosphonates, which are effectively used in the treatment of bone diseases. Although a number of properties of pamidronate have been recognized which influence the metabolic process in bones, the issue of the effect of bisphosphonates on the function of blood circulation and autonomic nervous system in osteoporotic bones remains open. In order to clarify th...
متن کامل